Description
Benquil™ is an oral formulation of Midazolam, a short-acting benzodiazepine known for its rapid onset and brief duration. This hypnotic agent also provides anxiolytic, muscle‑relaxant, and anticonvulsant effects by potentiating GABA-A receptor-mediated inhibition.
✔️ Indications & Therapeutic Class
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Short-term treatment of insomnia
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Premedication sedation prior to surgeries or diagnostic procedures
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Therapeutic class: Benzodiazepine hypnotics / sedatives
💊 Dosage & Administration
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Oral (adults): 7.5–15 mg once daily at bedtime
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Elderly / debilitated: 7.5 mg once at night
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Premedication: 7.5–15 mg orally 30–60 minutes before procedures
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Intravenous (endoscopy/cardio): initial dose ~2.5 mg (reduce to 1–1.5 mg in elderly or ill)
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IM for anesthesia induction: ~5 mg (0.07–0.1 mg/kg)
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Children: IM or rectal doses per body weight; in infants rectal midazolam may be used 20–30 minutes prior to anesthesia (0.35–0.45 mg/kg)
Treatment duration should not exceed 2 weeks unless advised medically.
⚠️ Contraindications & Precautions
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Avoid in severe respiratory or hepatic insufficiency, myasthenia gravis, sleep apnea, or known benzodiazepine sensitivity
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Risk of dependence and withdrawal—taper gradually after extended use
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Use cautiously during pregnancy or lactation; avoid unless benefits outweigh risks
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Co-administration with CNS depressants (e.g. alcohol, opioids, antihistamines) increases sedation risk
🚨 Side Effects
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Common: daytime drowsiness, fatigue, confusion, muscle weakness, headache—frequently diminish with continued use
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Parenteral use: may induce respiratory depression, hypotension, apnea, and vital sign fluctuations
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Overdose: potential coma, cardiorespiratory depression—managed with flumazenil when necessary
🔗 Drug Interactions
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Enhances sedation when combined with antidepressants, antipsychotics, analgesics, antihistamines, CNS depressants
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CYP3A inhibitors (e.g. azole antifungals, erythromycin, cimetidine) increase midazolam levels
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Avoid alcohol during therapy; patients should be warned of sedative synergy
🧪 Pharmacology & Mechanism
Midazolam binds to GABA-A benzodiazepine receptors in the limbic system and reticular formation, increasing neuronal chloride influx, stabilizing membrane potential, and producing inhibitory CNS effects: sedation, muscle relaxation, anxiolysis, and anticonvulsion.
🧪 Storage Instructions
Store in a cool, dry place sheltered from light and moisture. Keep out of reach of children.
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